An Integrated In Silico Approach to Design Specific Inhibitors Targeting Human Poly(A)-Specific Ribonuclease

Poly(A)-specific ribonuclease (PARN) is an exoribonuclease/deadenylase that degrades 3′-end poly(A) tails in almost all eukaryotic organisms. Much of the biochemical and structural information on PARN comes from the human enzyme. However, the existence of PARN all along the eukaryotic evolutionary l...

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Detalhes bibliográficos
Main Authors: Vlachakis, Dimitrios, Pavlopoulou, Athanasia, Tsiliki, Georgia, Komiotis, Dimitri, Stathopoulos, Constantinos, Balatsos, Nikolaos A. A., Kossida, Sophia
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3516499/
https://ncbi.nlm.nih.gov/pubmed/23236441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0051113
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