An Integrated In Silico Approach to Design Specific Inhibitors Targeting Human Poly(A)-Specific Ribonuclease

Poly(A)-specific ribonuclease (PARN) is an exoribonuclease/deadenylase that degrades 3′-end poly(A) tails in almost all eukaryotic organisms. Much of the biochemical and structural information on PARN comes from the human enzyme. However, the existence of PARN all along the eukaryotic evolutionary l...

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Detaylı Bibliyografya
Asıl Yazarlar: Vlachakis, Dimitrios, Pavlopoulou, Athanasia, Tsiliki, Georgia, Komiotis, Dimitri, Stathopoulos, Constantinos, Balatsos, Nikolaos A. A., Kossida, Sophia
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2012
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3516499/
https://ncbi.nlm.nih.gov/pubmed/23236441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0051113
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