Impact of Prefrontal Cortex in Nicotine-Induced Excitation of Ventral Tegmental Area Dopamine Neurons in Anesthetized Rats

Systemic administration of nicotine increases dopaminergic (DA) neuron firing in the ventral tegmental area (VTA), which is thought to underlie nicotine reward. Here, we report that the medial prefrontal cortex (mPFC) plays a critical role in nicotine-induced excitation of VTA DA neurons. In chloral...

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Main Authors: Zhang, Die, Gao, Ming, Xu, Dan, Shi, Wei-Xing, Gutkin, Boris S., Steffensen, Scott C., Lukas, Ronald J., Wu, Jie
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2012
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3516404/
https://ncbi.nlm.nih.gov/pubmed/22956827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5411-11.2012
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