Human Genome-Wide Association and Mouse Knockout Approaches Identify Platelet Supervillin as an Inhibitor of Thrombus Formation under Shear Stress

BACKGROUND: High shear force critically regulates platelet adhesion and thrombus formation during ischemic vascular events. To identify genetic factors that influence platelet thrombus formation under high shear stress, we performed a genome-wide association study (GWAS) and confirmatory experiments...

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Main Authors: Edelstein, Leonard C., Luna, Elizabeth J., Gibson, Ian B., Bray, Molly, Jin, Ying, Kondkar, Altaf, Nagalla, Srikanth, Hadjout-Rabi, Nacima, Smith, Tara C., Covarrubias, Daniel, Jones, Stephen N., Ahmad, Firdos, Stolla, Moritz, Kong, Xianguo, Fang, Zhiyou, Bergmeier, Wolfgang, Shaw, Chad, Leal, Suzanne M., Bray, Paul F.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3515852/
https://ncbi.nlm.nih.gov/pubmed/22550155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.112.091462
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