Peroxisome proliferator-activated receptor γ coactivator 1-α gene transfer restores mitochondrial biomass and improves mitochondrial calcium handling in post-necrotic mdx mouse skeletal muscle

Alterations of mitochondrial function have been implicated in the pathogenesis of Duchenne muscular dystrophy. In the present study, mitochondrial respiratory function, reactive oxygen species (ROS) dynamics and susceptibility to Ca(2+)-induced permeability transition pore (PTP) opening were investi...

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Detalhes bibliográficos
Main Authors: Godin, Richard, Daussin, Frederic, Matecki, Stefan, Li, Tong, Petrof, Basil J, Burelle, Yan
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2012
Assuntos:
Skeletal Muscle and Exercise
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3515833/
https://ncbi.nlm.nih.gov/pubmed/22907054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2012.240390
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