WIKI4, a Novel Inhibitor of Tankyrase and Wnt/ß-Catenin Signaling

The Wnt/ß-catenin signaling pathway controls important cellular events during development and often contributes to disease when dysregulated. Using high throughput screening we have identified a new small molecule inhibitor of Wnt/ß-catenin signaling, WIKI4. WIKI4 inhibits expression of ß-catenin ta...

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Detalhes bibliográficos
Main Authors: James, Richard G., Davidson, Kathryn C., Bosch, Katherine A., Biechele, Travis L., Robin, Nicholas C., Taylor, Russell J., Major, Michael B., Camp, Nathan D., Fowler, Kerry, Martins, Timothy J., Moon, Randall T.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3515623/
https://ncbi.nlm.nih.gov/pubmed/23227175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0050457
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