The hMSH2(M688R) Lynch syndrome mutation may function as a dominant negative

The hMSH2(M688R) mismatch repair (MMR) gene mutation has been found in five large families from Tenerife, Spain, suggesting it is a Lynch syndrome or hereditary non-polyposis colorectal cancer (LS/HNPCC) founder mutation. In addition to classical LS/HNPCC tumors, these families present with a high i...

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Bibliografiske detaljer
Main Authors: Martín-López, Juana V., Barrios, Ysamar, Medina-Arana, Vicente, Andújar, Miguel, Lee, Sanghee, Gu, Liya, Li, Guo-Min, Rüschoff, Josef, Salido, Eduardo, Fishel, Richard
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2012
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Original Manuscript
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3514906/
https://ncbi.nlm.nih.gov/pubmed/22739024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgs199
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