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The hMSH2(M688R) Lynch syndrome mutation may function as a dominant negative
The hMSH2(M688R) mismatch repair (MMR) gene mutation has been found in five large families from Tenerife, Spain, suggesting it is a Lynch syndrome or hereditary non-polyposis colorectal cancer (LS/HNPCC) founder mutation. In addition to classical LS/HNPCC tumors, these families present with a high i...
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Main Authors: | , , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Oxford University Press
2012
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3514906/ https://ncbi.nlm.nih.gov/pubmed/22739024 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgs199 |
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