Chemopreventive sphingadienes downregulate Wnt signaling via a PP2A/Akt/GSK3β pathway in colon cancer

Sphingadienes (SDs) derived from soy and other natural sphingolipids are cytotoxic to colon cancer cells via an Akt-dependent mechanism and reduce adenoma formation in Apc (Min/+) mice. Wnt signaling is fundamental to colon carcinogenesis and is the basis for spontaneous tumorigenesis in Apc (Min/+)...

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Autores principales: Kumar, Ashok, Pandurangan, Ashok K., Lu, Fang, Fyrst, Henrik, Zhang, Meng, Byun, Hoe-Sup, Bittman, Robert, Saba, Julie D.
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2012
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3514901/
https://ncbi.nlm.nih.gov/pubmed/22581840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgs174
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