Sorafenib enhances the therapeutic efficacy of rapamycin in colorectal cancers harboring oncogenic KRAS and PIK3CA

Activation of phosphatidylinositol 3-kinase (PI3K)/Akt signaling is associated with tumorigenesis and metastasis of colorectal cancer (CRC). The mammalian target of rapamycin (mTOR) kinase, a downstream effector of PI3K/Akt signaling, regulates tumorigenesis and metastasis of CRCs, indicating that m...

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Autori principali: Gulhati, Pat, Zaytseva, Yekaterina Y, Valentino, Joseph D, Stevens, Payton D, Kim, Ji Tae, Sasazuki, Takehiko, Shirasawa, Senji, Lee, Eun Y, Weiss, Heidi L, Dong, Jianli, Gao, Tianyan, Evers, B. Mark
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3514899/
https://ncbi.nlm.nih.gov/pubmed/22696593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgs203
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