Functional Dissection of the Epidermal Growth Factor Receptor Epitopes Targeted by Panitumumab and Cetuximab

Cetuximab and panitumumab, two antibodies targeting the extracellular domain of the epidermal growth factor receptor (EGFR), are of major clinical importance particularly in the treatment of metastatic colorectal cancer. As patients may acquire resistance-mediating mutations within the extracellular...

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Bibliographic Details
Main Authors: Voigt, Mareike, Braig, Friederike, Göthel, Markus, Schulte, Alexander, Lamszus, Katrin, Bokemeyer, Carsten, Binder, Mascha
Format: Artigo
Language:Inglês
Published: Neoplasia Press Inc. 2012
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3514746/
https://ncbi.nlm.nih.gov/pubmed/23226096
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