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Probing the structural basis for differential KCNQ1 modulation by KCNE1 and KCNE2
KCNE1 associates with KCNQ1 to increase its current amplitude and slow the activation gating process, creating the slow delayed rectifier channel that functions as a “repolarization reserve” in human heart. The transmembrane domain (TMD) of KCNE1 plays a key role in modulating KCNQ1 pore conductance...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The Rockefeller University Press
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3514736/ https://ncbi.nlm.nih.gov/pubmed/23183700 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201210847 |
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