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Pharmacokinetic Analysis of Ziconotide (SNX-111), an Intrathecal N-type Calcium Channel Blocking Analgesic, Delivered by Bolus and Infusion in the Dog
BACKGROUND AND PURPOSE: Ziconotide is a peptide that blocks N-type calcium channels and is anti-hyperalgesic after intrathecal delivery. We here characterize the spinal kinetics of intrathecal bolus and infused ziconotide in dog. EXPERIMENTAL APPROACH: Male beagle dogs (N = 5) were prepared with chr...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3514653/ https://ncbi.nlm.nih.gov/pubmed/22748108 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1525-1403.2012.00479.x |
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