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Optimizing the Concentration and Bolus of a Drug Delivered by Continuous Infusion

We consider treatment regimes in which an agent is administered continuously at a specified concentration until either a response is achieved or a predetermined maximum infusion time is reached. Response is an event defined to characterize therapeutic efficacy. A portion of the maximum planned total...

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Detalhes bibliográficos
Main Authors: Thall, Peter F., Szabo, Aniko, Nguyen, Hoang Q., Amlie-Lefond, Catherine M., Zaidat, Osama O.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3137757/
https://ncbi.nlm.nih.gov/pubmed/21401568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1541-0420.2011.01580.x
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