Pharmacokinetic Analysis of Ziconotide (SNX-111), an Intrathecal N-type Calcium Channel Blocking Analgesic, Delivered by Bolus and Infusion in the Dog

BACKGROUND AND PURPOSE: Ziconotide is a peptide that blocks N-type calcium channels and is anti-hyperalgesic after intrathecal delivery. We here characterize the spinal kinetics of intrathecal bolus and infused ziconotide in dog. EXPERIMENTAL APPROACH: Male beagle dogs (N = 5) were prepared with chr...

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Bibliographic Details
Main Authors: Yaksh, Tony L., de Kater, Annelies, Dean, Robin, Best, Brookie M., Miljanich, George P.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3514653/
https://ncbi.nlm.nih.gov/pubmed/22748108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1525-1403.2012.00479.x
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