Characteristics of TBS-extractable hyperphosphorylated tau species: Aggregation intermediates in rTg4510 mouse brain

Conditional overexpression of four-repeat human tau containing the P301L missense mutation in the rTg4510 mouse model of tauopathy leads to progressive accumulation of neurofibrillary tangles and hyperphosphorylated, sarkosyl-insoluble tau species, which are biochemically comparable to abnormal tau...

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Autors principals: Sahara, Naruhiko, DeTure, Michael, Ren, Yan, Ebrahim, Abdul-Shukkur, Kang, Dongcheul, Knight, Joshua, Volbracht, Christiane, Pedersen, Jan Torleif, Dickson, Dennis W., Yen, Shu-Hui, Lewis, Jada
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3514650/
https://ncbi.nlm.nih.gov/pubmed/22941973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-2012-121093
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