Fibrin Clot Structure and Mechanics Associated with Specific Oxidation of Methionine Residues in Fibrinogen

Using a combination of structural and mechanical characterization, we examine the effect of fibrinogen oxidation on the formation of fibrin clots. We find that treatment with hypochlorous acid preferentially oxidizes specific methionine residues on the α, β, and γ chains of fibrinogen. Oxidation is...

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Bibliografiske detaljer
Main Authors: Weigandt, Katie M., White, Nathan, Chung, Dominic, Ellingson, Erica, Wang, Yi, Fu, Xiaoyun, Pozzo, Danilo C.
Format: Artigo
Sprog:Inglês
Udgivet: The Biophysical Society 2012
Fag:
Systems Biophysics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3514520/
https://ncbi.nlm.nih.gov/pubmed/23283239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2012.10.036
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