Fibrin Clot Structure and Mechanics Associated with Specific Oxidation of Methionine Residues in Fibrinogen

Using a combination of structural and mechanical characterization, we examine the effect of fibrinogen oxidation on the formation of fibrin clots. We find that treatment with hypochlorous acid preferentially oxidizes specific methionine residues on the α, β, and γ chains of fibrinogen. Oxidation is...

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Main Authors: Weigandt, Katie M., White, Nathan, Chung, Dominic, Ellingson, Erica, Wang, Yi, Fu, Xiaoyun, Pozzo, Danilo C.
Format: Artigo
Jezik:Inglês
Izdano: The Biophysical Society 2012
Teme:
Systems Biophysics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3514520/
https://ncbi.nlm.nih.gov/pubmed/23283239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2012.10.036
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