Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation

Blood-brain barrier disruption, microglial activation and neurodegeneration are hallmarks of multiple sclerosis. However, the initial triggers that activate innate immune responses and their role in axonal damage remain unknown. Here we show that the blood protein fibrinogen induces rapid microglial...

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Detalhes bibliográficos
Main Authors: Davalos, Dimitrios, Kyu Ryu, Jae, Merlini, Mario, Baeten, Kim M., Le Moan, Natacha, Petersen, Mark A., Deerinck, Thomas J., Smirnoff, Dimitri S., Bedard, Catherine, Hakozaki, Hiroyuki, Gonias Murray, Sara, Ling, Jennie B., Lassmann, Hans, Degen, Jay L., Ellisman, Mark H., Akassoglou, Katerina
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3514498/
https://ncbi.nlm.nih.gov/pubmed/23187627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms2230
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