Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation

Blood-brain barrier disruption, microglial activation and neurodegeneration are hallmarks of multiple sclerosis. However, the initial triggers that activate innate immune responses and their role in axonal damage remain unknown. Here we show that the blood protein fibrinogen induces rapid microglial...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Davalos, Dimitrios, Kyu Ryu, Jae, Merlini, Mario, Baeten, Kim M., Le Moan, Natacha, Petersen, Mark A., Deerinck, Thomas J., Smirnoff, Dimitri S., Bedard, Catherine, Hakozaki, Hiroyuki, Gonias Murray, Sara, Ling, Jennie B., Lassmann, Hans, Degen, Jay L., Ellisman, Mark H., Akassoglou, Katerina
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Pub. Group 2012
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3514498/
https://ncbi.nlm.nih.gov/pubmed/23187627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms2230
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky