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β-Arrestins specifically constrain β2-adrenergic receptor signaling and function in airway smooth muscle
Chronic use of inhaled beta-agonists by asthmatics is associated with a loss of bronchoprotective effect and deterioration of asthma control. Beta-agonist-promoted desensitization of airway smooth muscle beta-2-adrenergic receptors, mediated by G protein-coupled receptor kinases and arrestins, is pr...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3514410/ https://ncbi.nlm.nih.gov/pubmed/18337459 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.07-102459 |
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