RNAi-mediated knock-down of Dab and Numb attenuate Aβ levels via γ-secretase mediated APP processing

Amyloid-β-protein (Aβ), the key component of senile plaques in Alzheimer's disease (AD) brain, is produced from amyloid precursor protein (APP) by cleavage of β-secretase and then γ-secretase. APP adaptor proteins with phosphotyrosine-binding (PTB) domains, including Dab (gene: DAB) and Numb (g...

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Detalhes bibliográficos
Main Authors: Xie, Zhongcong, Dong, Yuanlin, Maeda, Uta, Xia, Weiming, Tanzi, Rudolph E
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3514095/
https://ncbi.nlm.nih.gov/pubmed/23211096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2047-9158-1-8
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