PKA and PDE4D3 anchoring to AKAP9 provides distinct regulation of cAMP signals at the centrosome

Previous work has shown that the protein kinase A (PKA)–regulated phosphodiesterase (PDE) 4D3 binds to A kinase–anchoring proteins (AKAPs). One such protein, AKAP9, localizes to the centrosome. In this paper, we investigate whether a PKA–PDE4D3–AKAP9 complex can generate spatial compartmentalization...

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Detalhes bibliográficos
Main Authors: Terrin, Anna, Monterisi, Stefania, Stangherlin, Alessandra, Zoccarato, Anna, Koschinski, Andreas, Surdo, Nicoletta C., Mongillo, Marco, Sawa, Akira, Jordanides, Niove E., Mountford, Joanne C., Zaccolo, Manuela
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2012
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3514031/
https://ncbi.nlm.nih.gov/pubmed/22908311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201201059
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