Nilotinib potentiates anticancer drug sensitivity in murine ABCB1-, ABCG2-, and ABCC10-multidrug resistance xenograft models

A panel of clinically used tyrosine kinase inhibitors was compared and nilotinib was found to most potently sensitize specific anticancer agents by blocking the functions of ABCB1/P-glycoprotein, ABCG2/BCRP and ABCC10/MRP7 transporters involved in multi-drug resistance. Nilotinib appreciably enhance...

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Detalhes bibliográficos
Main Authors: Tiwari, Amit K., Sodani, Kamlesh, Dai, Chun-ling, Abuznait, Alaa H., Singh, Satyakam, Xiao, Zhi-Jie, Patel, Atish, Talele, Tanaji T., Fu, Liwu, Kaddoumi, Amal, Gallo, James M., Chen, Zhe-Sheng
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3513659/
https://ncbi.nlm.nih.gov/pubmed/23063650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2012.10.001
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