Epithelial-to-Mesenchymal Transition Induced by TGF-β1 is Mediated by Blimp-1-Dependent Repression of BMP-5

Induction of epithelial-to-mesenchymal transition (EMT) by TGF-β1 requires Ras signaling. We recently identified the transcriptional repressor Blimp-1 (PRDM1) as a downstream effector of the NF-κB, RelB/Bcl-2/Ras-driven pathway that promotes breast cancer cell migration. As the RelB/Blimp-1 pathway...

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Detalhes bibliográficos
Main Authors: Romagnoli, Mathilde, Belguise, Karine, Yu, Ziyang, Wang, Xiaobo, Landesman-Bollag, Esther, Seldin, David C., Chalbos, Dany, Barillé-Nion, Sophie, Jézéquel, Pascal, Seldin, Margaret L., Sonenshein, Gail E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3513653/
https://ncbi.nlm.nih.gov/pubmed/23054396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-2270
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