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Role of DNA polymerases in repeat-mediated genome instability
Expansions of simple DNA repeats cause numerous hereditary diseases in humans. We analyzed the role of DNA polymerases in the instability of Friedreich’s ataxia (GAA)(n) repeats in a yeast experimental system. The elementary step of expansion corresponded to ~160 bp in the wild type strain, matching...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3513503/ https://ncbi.nlm.nih.gov/pubmed/23142667 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2012.10.006 |
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