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Formation of Itraconazole–Succinic Acid Cocrystals by Gas Antisolvent Cocrystallization
Cocrystals of itraconazole, an antifungal drug with poor bioavailability, and succinic acid, a water-soluble dicarboxylic acid, were formed by gas antisolvent (GAS) cocrystallization using pressurized CO(2) to improve itraconazole dissolution. In this study, itraconazole and succinic acid were simul...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer US
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3513434/ https://ncbi.nlm.nih.gov/pubmed/23054991 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12249-012-9866-4 |
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