Identification and Pharmaceutical Characterization of a New Itraconazole Terephthalic Acid Cocrystal

The crystallization of poorly soluble drug molecules with an excipient into new solid phases called cocrystals has gained a considerable popularity in the pharmaceutical field. In this work, the cocrystal approach was explored for a very poorly water soluble antifungal active, itraconazole (ITR), wh...

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Bibliographic Details
Main Authors: Ricardo Machado Cruz, Tereza Boleslavská, Josef Beránek, Eszter Tieger, Brendan Twamley, Maria Jose Santos-Martinez, Ondřej Dammer, Lidia Tajber
Format: Artigo
Language:Inglês
Published: MDPI AG 2020-08-01
Series:Pharmaceutics
Subjects:
itraconazole
terephthalic acid
cocrystal
crystal structure
mechanochemistry
solid-state
Online Access:https://www.mdpi.com/1999-4923/12/8/741
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