Notch-RBP-J Signaling Regulates IRF8 to Promote Inflammatory Macrophage Polarization

Emerging concepts suggest that macrophage functional phenotype is regulated by transcription factors that define alternative activation states. We found that RBP-J, the major nuclear transducer of Notch signaling, augmented TLR4-induced expression of key mediators of classically activated M1 macroph...

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Hauptverfasser: Xu, Haixia, Zhu, Jimmy, Smith, Sinead, Foldi, Julia, Zhao, Baohong, Chung, Allen Y., Outtz, Hasina, Kitajewski, Jan, Shi, Chao, Weber, Silvio, Saftig, Paul, Li, Yueming, Ozato, Keiko, Blobel, Carl P., Ivashkiv, Lionel B., Hu, Xiaoyu
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3513378/
https://ncbi.nlm.nih.gov/pubmed/22610140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2304
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