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Organelle biogenesis: En BLOC exchange for RAB32 and RAB38
Prominent subtypes of the genetic disorder, Hermansky-Pudlak Syndrome, result from defects in a mysterious protein complex, BLOC-3. New work identifies BLOC-3 as a guanine nucleotide exchange factor for two Rab GTPases previously implicated in lysosome-related organelle biogenesis.
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3513372/ https://ncbi.nlm.nih.gov/pubmed/23174301 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2012.10.005 |
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