Reactive oxygen species regulate ERBB2 and ERBB3 expression via miR-199a/125b and DNA methylation

Overexpression of ERBB2 or ERBB3 is associated with cancer development and poor prognosis. In this study, we show that reactive oxygen species (ROS) induce both ERBB2 and ERBB3 expression in vitro and in vivo. We also identify that miR-199a and miR-125b target ERBB2 and/or ERBB3 in ovarian cancer ce...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: He, Jun, Xu, Qing, Jing, Yi, Agani, Faton, Qian, Xu, Carpenter, Richard, Li, Qi, Wang, Xin-Ru, Peiper, Stephen S, Lu, Zhimin, Liu, Ling-Zhi, Jiang, Bing-Hua
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: European Molecular Biology Organization 2012
Pynciau:
Scientific Reports
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3512405/
https://ncbi.nlm.nih.gov/pubmed/23146892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2012.162
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