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Defining a new role of GW182 in maintaining miRNA stability
GW182 binds to Argonaute (AGO) proteins and has a central role in miRNA-mediated gene silencing. Using lentiviral shRNA-induced GW182 knockdown in HEK293 cells, this study identifies a new role of GW182 in regulating miRNA stability. Stably knocking down GW182 or its paralogue TNRC6B reduces transfe...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
European Molecular Biology Organization
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3512404/ https://ncbi.nlm.nih.gov/pubmed/23090477 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2012.160 |
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