Mammalian proapoptotic factor ChaC1 and its homologues function as γ-glutamyl cyclotransferases acting specifically on glutathione

ChaC1 is a mammalian proapoptic protein of unknown function induced during endoplasmic reticulum stress. We show using in vivo studies and novel in vitro assays that the ChaC family of proteins function as γ-glutamyl cyclotransferases acting specifically to degrade glutathione but not other γ-glutam...

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Autors principals: Kumar, Akhilesh, Tikoo, Shweta, Maity, Shuvadeep, Sengupta, Shantanu, Sengupta, Sagar, Kaur, Amandeep, Kumar Bachhawat, Anand
Format: Artigo
Idioma:Inglês
Publicat: European Molecular Biology Organization 2012
Matèries:
Scientific Reports
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3512401/
https://ncbi.nlm.nih.gov/pubmed/23070364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2012.156
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