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Structural and Functional Analyses of Human ChaC2 in Glutathione Metabolism
Glutathione (GSH) degradation plays an essential role in GSH homeostasis, which regulates cell survival, especially in cancer cells. Among human GSH degradation enzymes, the ChaC2 enzyme acts on GSH to form 5-l-oxoproline and Cys-Gly specifically in the cytosol. Here, we report the crystal structure...
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| Pubblicato in: | Biomolecules |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
MDPI
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7022552/ https://ncbi.nlm.nih.gov/pubmed/31878259 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom10010031 |
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