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Structural and Functional Analyses of Human ChaC2 in Glutathione Metabolism

Glutathione (GSH) degradation plays an essential role in GSH homeostasis, which regulates cell survival, especially in cancer cells. Among human GSH degradation enzymes, the ChaC2 enzyme acts on GSH to form 5-l-oxoproline and Cys-Gly specifically in the cytosol. Here, we report the crystal structure...

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Detalhes bibliográficos
Publicado no:Biomolecules
Main Authors: Nguyen, Yen T. K., Park, Joon Sung, Jang, Jun Young, Kim, Kyung Rok, Vo, Tam T. L., Kim, Kyu-Won, Han, Byung Woo
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7022552/
https://ncbi.nlm.nih.gov/pubmed/31878259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom10010031
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