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Structural and Functional Analyses of Human ChaC2 in Glutathione Metabolism

Glutathione (GSH) degradation plays an essential role in GSH homeostasis, which regulates cell survival, especially in cancer cells. Among human GSH degradation enzymes, the ChaC2 enzyme acts on GSH to form 5-l-oxoproline and Cys-Gly specifically in the cytosol. Here, we report the crystal structure...

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Dettagli Bibliografici
Pubblicato in:Biomolecules
Autori principali: Nguyen, Yen T. K., Park, Joon Sung, Jang, Jun Young, Kim, Kyung Rok, Vo, Tam T. L., Kim, Kyu-Won, Han, Byung Woo
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7022552/
https://ncbi.nlm.nih.gov/pubmed/31878259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom10010031
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