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SUMOylation Regulates the Transcriptional Repression Activity of FOG-2 and Its Association with GATA-4

Friend of GATA 2 (FOG-2), a co-factor of several GATA transcription factors (GATA-4, -5 and 6), is a critical regulator of coronary vessel formation and heart morphogenesis. Here we demonstrate that FOG-2 is SUMOylated and that this modification modulates its transcriptional activity. FOG-2 SUMOylat...

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Main Authors: Perdomo, José, Jiang, Xing-Mai, Carter, Daniel R., Khachigian, Levon M., Chong, Beng H.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2012
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3511347/
https://ncbi.nlm.nih.gov/pubmed/23226341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0050637
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