Splicing program of human MENA produces a previously undescribed isoform associated with invasive, mesenchymal-like breast tumors

Human mena (hMENA), a member of the actin cytoskeleton regulators Ena/VASP, is overexpressed in high-risk preneoplastic lesions and in primary breast tumors and has been identified as playing a role in invasiveness and poor prognosis in breast cancers that express HER2. Here we identify a unique iso...

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Sonraí Bibleagrafaíochta
Main Authors: Di Modugno, Francesca, Iapicca, Pierluigi, Boudreau, Aaron, Mottolese, Marcella, Terrenato, Irene, Perracchio, Letizia, Carstens, Russ P., Santoni, Angela, Bissell, Mina J., Nisticò, Paola
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2012
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3511125/
https://ncbi.nlm.nih.gov/pubmed/23129656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1214394109
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