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A mouse model for human deafness DFNB22 reveals that hearing impairment is due to a loss of inner hair cell stimulation
The gene causative for the human nonsyndromic recessive form of deafness DFNB22 encodes otoancorin, a 120-kDa inner ear-specific protein that is expressed on the surface of the spiral limbus in the cochlea. Gene targeting in ES cells was used to create an EGFP knock-in, otoancorin KO (Otoa(EGFP/EGFP...
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| Autori principali: | , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3511093/ https://ncbi.nlm.nih.gov/pubmed/23129639 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1210159109 |
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