A mouse model for human deafness DFNB22 reveals that hearing impairment is due to a loss of inner hair cell stimulation

The gene causative for the human nonsyndromic recessive form of deafness DFNB22 encodes otoancorin, a 120-kDa inner ear-specific protein that is expressed on the surface of the spiral limbus in the cochlea. Gene targeting in ES cells was used to create an EGFP knock-in, otoancorin KO (Otoa(EGFP/EGFP...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Lukashkin, Andrei N., Legan, P. Kevin, Weddell, Thomas D., Lukashkina, Victoria A., Goodyear, Richard J., Welstead, Lindsey J., Petit, Christine, Russell, Ian J., Richardson, Guy P.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2012
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3511093/
https://ncbi.nlm.nih.gov/pubmed/23129639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1210159109
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg