A mouse model for human deafness DFNB22 reveals that hearing impairment is due to a loss of inner hair cell stimulation

The gene causative for the human nonsyndromic recessive form of deafness DFNB22 encodes otoancorin, a 120-kDa inner ear-specific protein that is expressed on the surface of the spiral limbus in the cochlea. Gene targeting in ES cells was used to create an EGFP knock-in, otoancorin KO (Otoa(EGFP/EGFP...

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Detalhes bibliográficos
Main Authors: Lukashkin, Andrei N., Legan, P. Kevin, Weddell, Thomas D., Lukashkina, Victoria A., Goodyear, Richard J., Welstead, Lindsey J., Petit, Christine, Russell, Ian J., Richardson, Guy P.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3511093/
https://ncbi.nlm.nih.gov/pubmed/23129639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1210159109
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