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Estrogen Receptor α Signaling Regulates Breast Tumor-initiating Cells by Down-regulating miR-140 Which Targets the Transcription Factor SOX2

Several reports have indicated that miR-140, a possible tumor suppressor microRNA (miR), is down-regulated in breast tumors compared with normal breast tissues. However, the role of miR-140 in breast tumorigenesis is unclear. We initiated studies that examined estrogen receptor α (ERα) signaling in...

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Detalhes bibliográficos
Main Authors: Zhang, Yongshu, Eades, Gabriel, Yao, Yuan, Li, Qinglin, Zhou, Qun
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3510847/
https://ncbi.nlm.nih.gov/pubmed/23060440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.404871
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