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miR-200a Regulates Nrf2 Activation by Targeting Keap1 mRNA in Breast Cancer Cells

NF-E2-related factor 2 (Nrf2) is an important transcription factor that activates the expression of cellular detoxifying enzymes. Nrf2 expression is largely regulated through the association of Nrf2 with Kelch-like ECH-associated protein 1 (Keap1), which results in cytoplasmic Nrf2 degradation. Conv...

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Detalhes bibliográficos
Main Authors: Eades, Gabriel, Yang, Muhua, Yao, Yuan, Zhang, Yongshu, Zhou, Qun
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3220489/
https://ncbi.nlm.nih.gov/pubmed/21926171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.275495
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