HIV-1 Nef Impairs Heterotrimeric G-protein Signaling by Targeting Gα(i2) for Degradation through Ubiquitination

The HIV Nef protein is an important pathogenic factor that modulates cell surface receptor trafficking and impairs cell motility, presumably by interfering at multiple steps with chemotactic receptor signaling. Here, we report that a dominant effect of Nef is to trigger AIP4 E3 ligase-mediated Gα(i2...

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Detalhes bibliográficos
Main Authors: Chandrasekaran, Prabha, Buckley, Monica, Moore, Victoria, Wang, Long Qin, Kehrl, John H., Venkatesan, Sundararajan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3510845/
https://ncbi.nlm.nih.gov/pubmed/23071112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.361782
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