4-Demethylwyosine Synthase from Pyrococcus abyssi Is a Radical-S-adenosyl-l-methionine Enzyme with an Additional [4Fe-4S](+2) Cluster That Interacts with the Pyruvate Co-substrate

Wybutosine and its derivatives are found in position 37 of tRNA encoding Phe in eukaryotes and archaea. They are believed to play a key role in the decoding function of the ribosome. The second step in the biosynthesis of wybutosine is catalyzed by TYW1 protein, which is a member of the well establi...

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Autori principali: Perche-Letuvée, Phanélie, Kathirvelu, Velavan, Berggren, Gustav, Clemancey, Martin, Latour, Jean-Marc, Maurel, Vincent, Douki, Thierry, Armengaud, Jean, Mulliez, Etienne, Fontecave, Marc, Garcia-Serres, Ricardo, Gambarelli, Serge, Atta, Mohamed
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2012
Soggetti:
Enzymology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3510817/
https://ncbi.nlm.nih.gov/pubmed/23043105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.405019
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