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The Rab GTPase-Activating Protein TBC1D4/AS160 Contains an Atypical Phosphotyrosine-Binding Domain That Interacts with Plasma Membrane Phospholipids To Facilitate GLUT4 Trafficking in Adipocytes

The Rab GTPase-activating protein TBC1D4/AS160 regulates GLUT4 trafficking in adipocytes. Nonphosphorylated AS160 binds to GLUT4 vesicles and inhibits GLUT4 translocation, and AS160 phosphorylation overcomes this inhibitory effect. In the present study we detected several new functional features of...

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書誌詳細
主要な著者: Tan, Shi-Xiong, Ng, Yvonne, Burchfield, James G., Ramm, Georg, Lambright, David G., Stöckli, Jacqueline, James, David E.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3510527/
https://ncbi.nlm.nih.gov/pubmed/23045393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00761-12
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