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Kinetic and thermodynamic characterization of the reaction pathway of box H/ACA RNA-guided pseudouridine formation
The box H/ACA RNA-guided pseudouridine synthase is a complicated ribonucleoprotein enzyme that recruits substrate via both the guide RNA and the catalytic subunit Cbf5. Structural studies have revealed multiple conformations of the enzyme, but a quantitative description of the reaction pathway is st...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3510513/ https://ncbi.nlm.nih.gov/pubmed/23012266 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks882 |
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