Structure of the Shq1–Cbf5–Nop10–Gar1 complex and implications for H/ACA RNP biogenesis and dyskeratosis congenita

Shq1 is a conserved protein required for the biogenesis of eukaryotic H/ACA ribonucleoproteins (RNPs), including human telomerase. We report the structure of the Shq1-specific domain alone and in complex with H/ACA RNP proteins Cbf5, Nop10 and Gar1. The Shq1-specific domain adopts a novel helical fo...

Full description

Saved in:
Bibliographic Details
Main Authors: Li, Shuang, Duan, Jingqi, Li, Dandan, Ma, Shoucai, Ye, Keqiong
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2011
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3242979/
https://ncbi.nlm.nih.gov/pubmed/22117216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.427
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items