Genome-wide activation of latent donor splice sites in stress and disease

Sequences that conform to the 5′ splice site (5′SS) consensus are highly abundant in mammalian introns. Most of these sequences are preceded by at least one in-frame stop codon; thus, their use for splicing would result in pre-maturely terminated aberrant mRNAs. In normally grown cells, such introni...

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Sonraí Bibleagrafaíochta
Main Authors: Nevo, Yuval, Kamhi, Eyal, Jacob-Hirsch, Jasmine, Amariglio, Ninette, Rechavi, Gideon, Sperling, Joseph, Sperling, Ruth
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2012
Ábhair:
RNA
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3510495/
https://ncbi.nlm.nih.gov/pubmed/23002147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks834
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