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Genome-wide activation of latent donor splice sites in stress and disease

Sequences that conform to the 5′ splice site (5′SS) consensus are highly abundant in mammalian introns. Most of these sequences are preceded by at least one in-frame stop codon; thus, their use for splicing would result in pre-maturely terminated aberrant mRNAs. In normally grown cells, such introni...

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Detalhes bibliográficos
Main Authors: Nevo, Yuval, Kamhi, Eyal, Jacob-Hirsch, Jasmine, Amariglio, Ninette, Rechavi, Gideon, Sperling, Joseph, Sperling, Ruth
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
Assuntos:
RNA
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3510495/
https://ncbi.nlm.nih.gov/pubmed/23002147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks834
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