Genome-wide activation of latent donor splice sites in stress and disease

Sequences that conform to the 5′ splice site (5′SS) consensus are highly abundant in mammalian introns. Most of these sequences are preceded by at least one in-frame stop codon; thus, their use for splicing would result in pre-maturely terminated aberrant mRNAs. In normally grown cells, such introni...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Nevo, Yuval, Kamhi, Eyal, Jacob-Hirsch, Jasmine, Amariglio, Ninette, Rechavi, Gideon, Sperling, Joseph, Sperling, Ruth
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2012
Pynciau:
RNA
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3510495/
https://ncbi.nlm.nih.gov/pubmed/23002147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks834
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