Signaling from the Sympathetic Nervous System Regulates Hematopoietic Stem Cell Emergence during Embryogenesis

The first adult-repopulating hematopoietic stem cells (HSCs) emerge in the aorta-gonads-mesonephros (AGM) region of the embryo. We have recently identified the transcription factor Gata3 as being upregulated in this tissue specifically at the time of HSC emergence. We now demonstrate that the produc...

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Detalhes bibliográficos
Main Authors: Fitch, Simon R., Kimber, Gillian M., Wilson, Nicola K., Parker, Aimée, Mirshekar-Syahkal, Bahar, Göttgens, Berthold, Medvinsky, Alexander, Dzierzak, Elaine, Ottersbach, Katrin
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3510442/
https://ncbi.nlm.nih.gov/pubmed/23040481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2012.07.002
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