Allopregnanolone Reinstates Tyrosine Hydroxylase Immunoreactive Neurons and Motor Performance in an MPTP-Lesioned Mouse Model of Parkinson's Disease

Restorative/protective therapies to restore dopamine neurons in the substantia nigra pars compacta (SNpc) are greatly needed to effectively change the debilitating course of Parkinson's disease. In this study, we tested the therapeutic potential of a neurogenic neurosteroid, allopregnanolone, i...

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Główni autorzy: Adeosun, Samuel O., Hou, Xu, Jiao, Yun, Zheng, Baoying, Henry, Sherry, Hill, Rosanne, He, Zhi, Pani, Amar, Kyle, Patrick, Ou, Xiaoming, Mosley, Thomas, Farley, Jerry M., Stockmeier, Craig, Paul, Ian, Bigler, Steven, Brinton, Roberta Diaz, Smeyne, Richard, Wang, Jun Ming
Format: Artigo
Język:Inglês
Wydane: Public Library of Science 2012
Hasła przedmiotowe:
Research Article
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3510204/
https://ncbi.nlm.nih.gov/pubmed/23209637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0050040
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