Allopregnanolone Reinstates Tyrosine Hydroxylase Immunoreactive Neurons and Motor Performance in an MPTP-Lesioned Mouse Model of Parkinson's Disease

Restorative/protective therapies to restore dopamine neurons in the substantia nigra pars compacta (SNpc) are greatly needed to effectively change the debilitating course of Parkinson's disease. In this study, we tested the therapeutic potential of a neurogenic neurosteroid, allopregnanolone, i...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Adeosun, Samuel O., Hou, Xu, Jiao, Yun, Zheng, Baoying, Henry, Sherry, Hill, Rosanne, He, Zhi, Pani, Amar, Kyle, Patrick, Ou, Xiaoming, Mosley, Thomas, Farley, Jerry M., Stockmeier, Craig, Paul, Ian, Bigler, Steven, Brinton, Roberta Diaz, Smeyne, Richard, Wang, Jun Ming
التنسيق: Artigo
اللغة:Inglês
منشور في: Public Library of Science 2012
الموضوعات:
Research Article
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC3510204/
https://ncbi.nlm.nih.gov/pubmed/23209637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0050040
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